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High‐resolution molecular characterization of the HLA class I and class II in the Tarahumara Amerindian population

Identifieur interne : 000A84 ( Main/Exploration ); précédent : 000A83; suivant : 000A85

High‐resolution molecular characterization of the HLA class I and class II in the Tarahumara Amerindian population

Auteurs : J. E. García-Ortiz [Mexique] ; L. Sandoval-Ramírez [Mexique] ; H. Rangel-Villalobos [Mexique] ; H. Maldonado-Torres [Royaume-Uni] ; S. Cox [Royaume-Uni] ; C. A. García-Sepúlveda [Royaume-Uni] ; L. E. Figuera [Mexique] ; S. G. E. Marsh [Royaume-Uni] ; A. M. Little [Royaume-Uni] ; J. A. Madrigal [Royaume-Uni] ; J. Moscoso [Espagne] ; A. Arnaiz-Villena [Espagne] ; J. R. Argüello [Mexique]

Source :

RBID : ISTEX:C48509AFDE0F80EC3C1C8DA2C01544AB1B60B223

English descriptors

Abstract

We describe for the first time the high‐resolution profiling of HLA‐A, ‐B, ‐C, ‐DRB1, ‐DQB1 and ‐DPB1 in a culturally and geographically distinct Mexican ethnic group, the Tarahumaras. The alleles most frequently found by reference strand‐mediated conformational analysis in this population were for class I: HLA‐A*240201, *020101/09, *0206, *310102, *680102; HLA‐B*4002, *1501, *510201, *3501/02/03, *4005, *4801; HLA‐Cw*0304, *0801, *0102, *040101; and for class II: HLA‐DRB1*080201, *1402, *040701; HLA‐DQB1*0402, *0301, *0302/07; HLA‐DPB1*0402, *0401, *020102. In addition, a novel allele, HLA‐A*0257, was found. Based on comparison of presently known HLA‐DRB1 and ‐DQB1 allele frequencies in Amerindian groups and worldwide populations, the Tarahumaras are unexpectedly more related to the geographically and linguistically distant Aymara and Terena Amerindian groups than they are to neighbouring tribes.

Url:
DOI: 10.1111/j.1399-0039.2006.00636.x


Affiliations:


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Le document en format XML

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<div type="abstract" xml:lang="en">We describe for the first time the high‐resolution profiling of HLA‐A, ‐B, ‐C, ‐DRB1, ‐DQB1 and ‐DPB1 in a culturally and geographically distinct Mexican ethnic group, the Tarahumaras. The alleles most frequently found by reference strand‐mediated conformational analysis in this population were for class I: HLA‐A*240201, *020101/09, *0206, *310102, *680102; HLA‐B*4002, *1501, *510201, *3501/02/03, *4005, *4801; HLA‐Cw*0304, *0801, *0102, *040101; and for class II: HLA‐DRB1*080201, *1402, *040701; HLA‐DQB1*0402, *0301, *0302/07; HLA‐DPB1*0402, *0401, *020102. In addition, a novel allele, HLA‐A*0257, was found. Based on comparison of presently known HLA‐DRB1 and ‐DQB1 allele frequencies in Amerindian groups and worldwide populations, the Tarahumaras are unexpectedly more related to the geographically and linguistically distant Aymara and Terena Amerindian groups than they are to neighbouring tribes.</div>
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